2d 082-D08 (2D-08, 2',3',4'-trihydroxy flavone)SUMO 2-D08 SUMO UBC9-SUMO SUMO SUMO2-D08 is a cell permeable, mechanistically unique inhibitor of protein SUMOylation. 2-D08 also inhibits Axl with an IC50 of 0.49 nM. 2-D08 inhibits sumoylation by preventing transfer of